lumefantrine will lessen the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Prescription drugs are typically not suggested, provided that Unwanted effects will commonly outweigh the advantages.
Concomitant use of anticholinergic drugs may possibly bring about a hyporesponse to stimulation tests with secretin. Discontinue anticholinergic drugs not less than 5 fifty percent-lives just before administering secretin.
Remember that this medication continues to be prescribed since your medical doctor has judged the advantage to you is bigger than the potential risk of side effects. Many individuals working with this medication do not need significant Unintended effects.
fentanyl iontophoretic transdermal method and diazepam equally increase sedation. Keep away from or Use Alternate Drug. Restrict use to patients for whom different cure choices are inadequate
zafirlukast will enhance the degree or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Seizures and seizure-like action noted; weigh this potential threat against Gains ahead of prescribing therapy to individuals which has a historical past of seizures, together with People receiving anti-epileptic medication or who definitely have threat things that could decreased seizure threshold
Drugs which have amount restrictions connected with Each individual prescription. This restriction normally restrictions the quantity in the drug which will be covered.
pentobarbital will minimize the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Coadministration of encorafenib with delicate CYP3A4 substrates could bring about elevated toxicity or diminished efficacy of these agents.
tecovirimat will raise the stage or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Tecovirimat can be a weak inhibitor of CYP2C8 and CYP2C19. Watch for adverse consequences if coadministered with delicate substrates of those enzymes.
voriconazole will enhance the amount or outcome of diazepam by influencing hepatic/intestinal enzyme article CYP3A4 metabolism. Use Warning/Watch.
Cessation of benzodiazepines or other CNS depressants is chosen most often. In some cases, monitoring at a better standard of look after tapering CNS depressants might be proper. In Some others, gradually tapering a affected individual off of the prescribed benzodiazepine or other CNS depressant or reducing to the lowest helpful dose could possibly be suitable.
Stay clear of or substitute A different drug for these drugs when achievable. Evaluate for lack of therapeutic impact if medication must be coadministered. Alter dose In line with prescribing information if necessary.